Which project into the lumen of a major lactiferous duct

A 54-year-old woman complains of bloody discharge from her left nipple. Physical examination reveals a 0.5-cm nodule in the subareolar breast tissue, which is surgically excised. Histologic examination (shown in the image) reveals cuboidal and myoepithelial cell–lined vascular connective tissue cores, which project into the lumen of a major lactiferous duct. Which of the following is the appropriate diagnosis?

image

  1. Ductal carcinoma in situ
  2. Intraductal papilloma
  3. Lobular carcinoma in situ
  4. Medullary carcinoma
  5. Paget disease