Which of the following is a contraindication for usage of the drug cyclophosphamide?
Liver disease
Lung disease
Heart disease
Hypertension
Diabetes
Correct answer
Liver disease
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Cyclophosphamide is a nitrogen mustard alkylating agent that crosslinks DNA, making it useful in cancer treatment (such as leukemias). It is a pro-drug that undergoes bioactivation in the liver, and therefore advance hepatic disease will decrease its therapeutic activity.