Which of the following increases bone resorption?
A. Osteoprotegerin (OPG)
B. Oestrogen / testosterone
C. Mechanical loading
D. Interleukin 1
Correct answer : D. Interleukin 1
Interleukin 1 stimulates bone resorption and inhibits bone formation.
Osteoprotegerin is glycoprotein which acts as a decoy receptor for receptor activator of nuclear factor kappa B ligand (RANKL).
It prevents RANKL induced osteoclastic bone resorption. It is produced by osteoblasts.
Oestrogen, testosterone and mechanical loading inhibit bone resorption and stimulate bone formation.
Ref: Davidson’s Principles and Practice of Medicine, 22nd Edition, p1062