Which of the following is true regarding hereditary pancreatitis?
A. Autosomal recessive disorder
B. Has 80% penetrance
C. Accounts for about 30% of cases of chronic pancreatitis
D. IgG4 concentrations are elevated
Correct answer : B. Has 80% penetrance
Hereditary pancreatitis is an autosomal dominant disorder.
It has 80% penetrance.
It is associated with mutations in the cationic trypsinogen gene located on chromosome 7.
IgG4 concentrations are elevated in autoimmune pancreatitis.
Ref: Bailey and Love’s Short Practice of Surgery, 25th edition, p 1146.