The first twenty amino acids in the N-tail sequence of core histone H3 is MARTKQTARK STGGKAPRKQ. Epigenetics play an important role in dictating the expression of genes. Which of the following answer choices correctly pairs an amino acid with its potential epigenetic post-translation modification?
Arginine, methylation
Lysine, phosphorylation
Methionine, phosphorylation
Serine, acetylation
Threonine, methylation
Correct answer
Arginine, methylation
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correct answer: A
Acetylation by Histone Acetyltransferase (HAT) only occurs on lysine residues. Methylation by Histone Methyltransferase (HMTs) can occur on both lysine and arginine residues, and phosphorylation by serine/threonine- and tyrosine-specific kinases occurs on serine, threonine, and tyrosine residues.