In donovanosis-
a) Pseudolymphadenopathy
b) Penicillin is used for treatment
c) Painful ulcer
d) Suppurative lymphadenopathy
Correct Answer - A
Ans. is `a’ i.e., Pseudolymphadenopathy
Donovanosis
Caused by Calymmatobacterium granulomatis.
C. granulomatis is ?
Gram negative
Encapsulated
Nonmotile
Intracellular
It shares many morphologic and serologic characteristic (antigenic)
and > 99% homology at the nucleotide level with Klebsiella.
Clinical manifestations
IP → 1-4 weeks
Begins as one or more subcutaneous nodules that erode through
skin to produce clean, granulomatous, sharply defined, usually
painless lesions.
The genitalia are involved in 90% of cases.
Genital swelling, particularly of labia, is common.
In donovanosis, heaped-up granulomatous tissue may follow and via
subcutaneous extension to inguinal area may form “pseudo-
buboes”; however, the absence of true lymphadenopathy is the
hallmark of this infection.
Complications Pseudoelephantiasis, phimosis and paraphimosis
Diagnosis:
The preferred diagnostic method involves demonstration of typical
intracellular Donovan bodies within large mononuclear cells
visualized in smears prepared from lesions or biopsy specimens.
Stain used is wright - Giemsa
Treatment:
Azithromycin (DOC)
Doxycycline (2’d choice)
Chloramphenicol