Homeobox genes alter the position

NEET PG Biochemistry
#1
  1. Misexpression of which of the following homeobox genes alter the position of the forelimbs during development:
    a) HOXA7
    b) HOXB8
    c) HOXC9
    d) HOXDI0

Explanation:
Homeobox genes are a large family of similar genes that direct the formation of many body structures during early embryonic development.
Positioning of the limbs along the cranio-caudal axis in the flank regions of the embryo is regulated by the HOX genes expressed along this axis.
The cranial limit of expression of HOXB8 is at the cranial border of forelimb and misexpression of this gene alters the position of these limbs.
Answer: HOXB8
Ref: Langman’s Medical Embryology