Q-1. Which of the following is the muscle relaxant of choice in renal failure?
a) Rapacurium
b) Pancuronium
c) Atracurium
d) Rocuronium
Answer: Atracurium
Explanation:
Atracurium is a new, non-depolarizing muscle relaxant which rapidly breaks down in vivo and appears to require neither renal nor hepatic function for its elimination.
It is spontaneously broken down in the plasma by a non-enzymatic chemical process “Hofmann’s degradation”. Thus it is non-cumulative.
It could be used in patients with either liver or kidney disease.
It is the relaxant of choice in fragile patients and in renal failure.
Q-2. Which one of the following anti-bacterial should not be used with d-tubocurarine?
a) Norfloxacin
b) Streptomycin
c) Doxycycline
d) Cefotaxime
Answer: Streptomycin
Explanation:
Streptomycin can potentiate the action of d-tubocurarine and cause prolonged apnea.
All amino-glycosides including streptomycin reduce ACh release from motor nerve endings.
Q-3. Which of the following inhalational agents is the induction agent of choice in children?
a) Methoxyflurane
b) Sevoflurane
c) Desflurane
d) Isoflurane
Answer: Sevoflurane
Explanation:
Faster, pleasant and smooth induction with no significant systemic toxicity makes sevoflurane the agent of choice for induction especially in children.
Q-4. Which one of the following agents sensitizes the myocardium to catecholamines?
a) Isoflurane
b) Ether
c) Halothane
d) Propofol
Answer: Halothane
Explanation:
Halothane sensitizes the heart to adrenaline producing severe ventricular arrhythmias.
Q-5. Which of the following statements is not true about Etomidate?
a) It is intravenous anesthetic
b) It precipitates coronary insufficiency
c) It inhibits cortisol synthesis
d) It causes pain at site of injection
Answer: It precipitates coronary insufficiency
Explanation:
Cardiovascular and respiratory depressions do not occur with Etomidate.
It is potent, ultra-short acting non barbiturate intravenous anesthetics.