A 57yo man presents with weight loss

A 57yo man presents with weight loss, tiredness, fever and abdominal discomfort. Exam: spleen
palpable up to the umbilicus. Labs: WBC=127, Hgb=8.7, Plt=138. What is the most likely dx?
a. CML
b. AML
c. CLL
d. AML
e. Polycythemia

Q. 1. What is the key?
Q. 2. Why it is so diagnosed?
Ans. 1. The key is A. CML.
Ans. 2. Points in favour of CML: i) Age 57 years ii) weight loss iii) abdominal discomfort iv) anaemia v) fever vi) marked splenomegaly.