A 40-year-old female with a history of AIDS develops a herpes simplex keratitis of the eye. Which of the following antiviral agents should be administered in this case?
1.Zenamivir
2.Trifluridine
3.Zidovudine
4.Amantadine
5.Indinavir
Explanation
Trifluridine inhibits viral activity in HSV types 1 and 2, CMV, vaccinia, and perhaps adenovirus. It acts as a viral DNA synthesis inhibitor by irreversibly blocking thymidylate synthetase. Trifluridine triphosphate is a competitive inhibitor of thymidine triphosphate accumulation into DNA. It is used in the treatment of primary keratoconjunctivitis and recurrent epithelial keratitis caused by HSV 1 and 2.