Indian controls have agreed to start clinical trials of pancreatitis in patients of the corona virus, Sun Pharmaceutical Industries Ltd said that it has received approval and joins other Indian pharmaceutical companies conducting experiments in India for potential medicines for COVID 19 Which currently has no treatment or certified vaccine.
According to the report of “Reuters” Sun Pharma said that the drug of pancreatitis, navamstat has been identified as a potential candidate for patients of the corona virus by scientists at the University of Tokyo and the Lipentz Institute of Primary Research in Germany
In April the University of Tokyo announced plans to experiment with Nafamostat Mesilate and Camostat Mesilate, a licensed drug in Japan and South Korea to treat chronic pancreatitis.
Source: Day
30/5/2020
Camostat
Camostat Mesilate tablets 100 mg 100 tbaltes (Foipan)
Camostat is a serine protease inhibitor. Serine protease enzymes have a variety of functions in the body, and so camostat has a diverse range of uses. Camostat is approved in Japan for the treatment of chronic pancreatitis and postoperative reflux esophagitis. The manufacturer is Ono Pharmaceutical. The drug is used in the treatment of some forms of cancer and is also effective against some viral infections, as well as inhibiting fibrosis in liver or kidney disease or pancreatitis.
It is an inhibitor of the enzyme transmembrane protease, serine 2 (TMPRSS2). Inhibition of TMPRSS2 partially blocked infection by SARS-CoV and Human coronavirus NL63 in HeLa cell cultures. Another in vitro study showed that camostat significantly reduces the infection of Calu-3 lung cells by SARS-CoV-2, the virus responsible for COVID-19.
For chronic pancreatitis camostat’s typical dose is 600 mg daily, for postoperative reflux esophagitis 300 mg are taken. The daily dose is split in 3 doses and taken after each meal.
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