Which vitamin for function is required by Acetyl CoA carboxylase ?
a.Thiamin
b.Riboflavin
c.Biotin
d.Niacin
Solution;
In the initial reaction for the carboxylation of acetyl-CoA to malonyl-CoA which occurs in the presence of ATP
and acetyl-CoA carboxylase,bicarbonate as a source of CO2 is needed.
B vitamin biotin is required by the acetyl-CoA carboxylase.
Acetyl-CoA carboxylase reffers to a multinezyme protein consisting of variable number of identical sub-units each containing
Biotin
Biotin carboxylase
Biotin carboxyl carrier protein and transcarboxylase
A regulatory allosteric site
Ref: Harper 28th edition,chapter33.