Which one of the following is true of this condition?

A 58-year-old man was treated with tissue plasminogen activator after an anterior myocardial infarction and then admitted to the hospital. He was given intravenous unfractionated heparin. Four days later, discoloration of his feet and hands is noted. Which one of the following is true of this condition?

image
image

a. It is associated with concurrent use of acetylsalicylic acid
b. Cessation of smoking prevents progression of this illness
c. Urine eosinophils are common
d. Antigen-antibody interactions may be causative
e. Optimal treatment includes continuation of heparin therapy