A 56-year-old man has had increasing abdominal enlargement for 6 months. During the past 2 days, he developed a high fever. On physical examination, his temperature is 38.5°C. The abdomen is enlarged and diffusely tender, and there is a fluid wave. Paracentesis yields 500 mL of cloudy yellowish fluid. The cell count is 532/μL with 98% neutrophils and 2% mononuclear cells. A blood culture is positive for Escherichia coli. The patient dies. The gross appearance of the liver at autopsy is shown in the figure. Which of the following underlying diseases most commonly accounts for these findings?
- α1M-Antitrypsin deficiency
- HEV infection
- Hereditary hemochromatosis
- Primary sclerosing cholangitis
- Chronic alcoholism