A 70-year-old man with hypertension is treated with lisinopril. He is later switched from lisinopril to losartan. Which of the following is true regarding lisinopril and losartan?
1.They are both direct inhibitors of angiotensin I
2.They have different side-effect profiles
3.They both have a half life of 12 hours
4.Enalapril shares a mechanism of action with both
5.Aliskerin shares a mechanism of action with both
exp:
Patients who experience cough or angioedema with angiotensin-converting enzyme (ACE) inhibitors may be prescribed (angiotensin receptor blockers (ARBs) since an adverse reaction to one class does not predict an adverse reaction to the other.
Captopril, lisinopril, and the other ACE inhibitors inhibit angiotensin converting enzyme. Losartan, valsartan and other ARBs are angiotensin II type 1 receptor blockers. Cough and angioedema occur with both ACE inhibitors and ARBs but are less frequently observed with ARBs. Evidence has shown that patients failing ACE inhibitor therapy may be prescribed ARBs with reduced likelihood of experiencing the same side effects.
Illustration A highlights the different mechanisms of action of ACE inhibitors and ARBs.