Which of the following etiologic agents is most likely associated with the development of this lesion?

A 60-year-old woman presents with a 5-month history of “sinus pressure.” A 2-cm firm lesion is identified in the right lateral nasal wall. A CT scan reveals involvement of the adjacent paranasal sinus. A biopsy (shown in the image) displays epithelial nests protruding into the submucosa with uniform cellular proliferation and no atypia. Which of the following etiologic agents is most likely associated with the development of this lesion?

image

  1. Cytomegalovirus
  2. Epstein-Barr virus
  3. Herpes simplex virus type 1
  4. Human papillomavirus types 6 and 11
  5. Toxoplasma gondii