Which of the following decreases bone resorption?
A. Receptor activator of nuclear factor kappa B ligand (RANKL)
B. Interleukin 1
D. Tumour necrosis factor
Correct answer : C. Osteoprotegerin
Osteoclasts on the surface of a bone
Osteoprotegerin is glycoprotein which acts as a decoy receptor for receptor activator of nuclear factor kappa B ligand (RANKL).
It prevents RANKL induced conversion of osteoclast precursors to osteoclasts.
It is produced by osteoblasts.
All the other factors mentioned increase bone resorption.
Ref: Davidson’s Principles and Practice of Medicine, 22nd Edition, p1062