Which of the following cellular structures would be expected in the serum of this patient?

A 55-year-old man presents with recurrent nosebleeds. He complains of persistent runny nose, fever, malaise, and a 20-lb (9-kg) weight loss. Physical examination reveals a “saddle nose” deformity (patient shown in the image). An X-ray film of the chest shows patchy infiltrates. Urinalysis discloses 2+ hematuria. Antibodies directed to which of the following cellular structures would be expected in the serum of this patient?

image

  1. Epithelial nuclei
  2. Mitochondria
  3. Neutrophil cytoplasm
  4. Skeletal muscle
  5. Smooth muscle