Which among the following anti-arrhythmic medications are poorly tolerated in chronic therapy

Which among the following anti-arrhythmic medications are poorly tolerated in chronic therapy such that 40% of patients after 6 months discontinue the use of the drug due to the development of hypotension (especially if with IV use) and nausea.

A. Quinidine
B. Procainamide
C. Propefanone
D. Lidocaine
E. Flecainide