A 48-year-old man has undergone a gradual personality change over the past 6 months with increasing moodiness and irritability During your examination you note some choreiform involuntary movements and also recognize some cognitive impairment. What on MRI see below is likely to be the cause of his problem?
A areas of demyelination of the white matter
B atrophy and loss of neurons of the caudate nucleus
C loss of pigmented neurons of the substantia nigra
D neurons ballooned with cytoplasmic vacuoles
E selective atrophy of anterior frontal and temporal lobes