Useful therapy for improving fertility in polycystic ovarian syndrome (PCOS) includes which of the
following?
Cyproterone acetate
Ethinyloestradiol
Glibenclamide
Metformin This is the correct answer
Spironolactone
Metformin has been shown to increase the rate of conception in PCOS through improved insulin
sensitivity (although studies have not been powered to show a significant impact on pregnancy
outcome).
Ethinyloestradiol and cyproterone acetate combine to form Dianette the oral contraceptive.
Cyproterone acetate is also used as an anti-androgen for hormonal treatment of prostatic carcinoma.
Spironolactone is used for hirsutism but is teratogenic.
Glibenclamide is not used in PCOs.