True about clomiphene citrate is:
1.Enclomiphene has antiestrogenic effect
2.Chance of pregnancy is there fold as compared to placebo
3.Risk of multiple pregnancy is 2-4%
4.It can also be used for male infertility with oligozoospermia
View explanation
Clomiphene citrate :
Clomiphene citrate is the first line intervention for medical induction of ovulation in almost all circumstances, clomiphene acts purely as an antagonist or antiestrogen.
Thus clomiphene is used for anovulation and is the DOC for PCOD patients.
Clomiphene is a racemic mixture of zuclomiphene enclomiphene. Hence, all actions of clomiphene will be the actions of both these isomers.
Indications :
Anovulatory infertility in case of PCOS (Stein-Leventhal syndrome), Chiari frommel syndrome.
Amenorrhea and anovulation following the use of OCP’s (Post pill amenorrhea).
In vitro fertilization, GIFT technique and Assisted Reproduction Technique.
“It is the usual first choice for ovulation induction in most patients because of relative safety, efficacy, route of administration and relative low cost”.
Novak 14th/ed p 64
Results : 80-85% treated women ovulate and 40-50% conceive after the use of Clomiphene.