As a Molecular Cell Biologist, I was under the impression that Science means purely living organism and subjects like mathematics, chemistry and physics look alien to me always and poor at math’s till today. I hated the subjects most as I did not understand them and felt these subjects have no role in biology.
Well am familiar with Biophysics, Biochemistry, Computational Biology, but never bothered to know the deeper meaning of the subjects. Being editor at Bio standups everyday is a new experience and new learning, in this path I learned now that the Physics, Chemistry and Mathematics are core to biology. The biology I known far ages originates from the root of these three subjects.
You might wonder why am talking like school kid who tries to explain everything to a mother. Well that’s the summary of my recent participation at BTCS-NCBS (2016), things I learned and felt after the BTCS-NCBS (2016).
Dr. Mukund thattai and team organised a three-day international event “The Interface of Biology and Theoretical Computer Science Monday Dec 19 – Wednesday Dec 21, 2016 at Dasheri Auditorium, NCBS, Bangalore, India. Co-funded by Simons Foundation and NCBS.
The engagement amongst science and hypothetical computer science has achieved an energising stage. BTCS-NCBS team planed to assume a basic part in sustaining this interface. In this soul, they have interestingly united individuals from the controls of theoretical computer science (TCS), data sciences, biology and physics who have pondered these issues. This meeting provided research updates and additionally gave a reasonable diagram of these particular fields, permitting members to find intriguing cross-associations. The BTCS event had following categorical sessions.
Populations & Communication
Evolution & Sequences
Molecules & Information
Cells & Timing
Brains & Networks.
The event provided valuable guidance to the researchers who are at crossroads of Biology and Computational science. Some of the researchers who attended the event expressed their feelings and benefits of event. The event was very useful to find future career possibilities for transiting biologists and theoretical scientists. There were many informative talks took place during the affair.
Highlights:
Professor Raghavendra Gadagkar (IISC-India) Credit @ Sabeera/Biostandups
Professor Raghavendra Gadagkar (IISC-India) delivered lecture on “Cooperation and conflict in a tropical insect society”. Prof. Raghvendra shared details about “The Social Biology of Ropalidia marginata (commonly known as wasp)”. The researcher Raghavendra Gadagkar concentrates on the single species he has chipped away at all through his vocation. Found all through southern India, Ropalidia marginata is a primitively eusocial wasp—animal categories in which rulers and laborers don’t contrast morphologically and even the last hold the capacity to imitate. New settlements might be established by a solitary ripe female or by a few, which then share conceptive and labourer obligations.
R. marginata has furnished Gadagkar with a special chance to concentrate the development of eusociality; its seemingly perpetual traditions can proceed uncertainly, as old or debilitated rulers are supplanted by youthful and solid ones and new provinces are established consistently. Seeing such primitively eusocial species is pivotal, Gadagkar contends, on the off chance that we are to comprehend the development of the more prominent degrees of sociality found in other wasp species and in ants, termites, and honey bees. His times of study have persuaded that natural, physiological, and statistic variables can be more vital than hereditary relatedness in the determination for or against social attributes.
Dr. Nisheeth K. Vishnoi, EFPL-Switzerland. Credit @ Sabeera/Biostandups
“Evolution and computation” by Nisheeth K. Vishnoi (EFPL-Switzerland), showed an abnormal state prologue to advancement and to how we can utilize numerical apparatuses, for example, dynamical frameworks and Markov chains to model it. Inquiries regarding advancement then mean inquiries concerning dynamical frameworks and Markov chains – some are anything but difficult to answer while others indicate expanding openings in current methods in calculations and improvement. Specifically, in this post, we introduce a setting which catches the advancement of infections and figure the question How rapidly could development happen? This question is not just pertinent for the practicality of medication outline procedures to counter infections; it likewise prompts to non-unimportant inquiries in software engineering.
Dr. Jyotsna Dhawan, InStem-India. Credit @ Sabeera/Biostandups
Dr. Jyotsna Dhawan (InStem-India) distributed knowledge on “Choosing cell fates”. Like incognito agents, grown-up undifferentiated cells lie torpid in the tissues of grown-up vertebrates, and can quickly enact because of ecological signs. Their central goal in any case, is not dangerous but rather valuable: to repair and recover harmed tissue, and abandon duplicates of themselves for future eccentric episodes of harm control. While the cells of the early developing life multiply quickly, self-collecting to shape the developing life form, most cells in the grown-up mammalian body have stopped partitioning and get capacities that are normal for every tissue.
For instance, in skeletal muscle, the contractile strands in charge of development, express a muscle-particular hereditary program to create and amass standard, rehashing varieties of contractile proteins that react to nerve driving forces. Connected with these muscle strands are uncommon occupant undeveloped cells that incidentally sit without moving in a resting state called peacefulness. By turning around the captured cell division program these torpid forebear cells can make new cells, adapting to routine wear and tear and also scenes of damage. A crucial unanswered question concerns how multiplying cells pick between two non-separating destinies: separating into tissue particular cells or resting as calm foundational microorganisms. The results of this decision are basic to regenerative science, tumor and degenerative infection.
Dr. Timothy Saunders MBI-National University of Singapore, Singapore. Credit @ Sabeera/Biostandups
“Mechanics of development”- under this title Timothy Saunders (Mechanobiology Institute, Singapore (MBI), National University of Singapore-Singapore) offered how organic frameworks figure out how to capacity so dependably notwithstanding the inescapable nearness of noise (i.e. how is nature “robust”?). There are various potential wellsprings of mistake for living life forms, going from biochemical changes inside single cells to example to-example changeability. Creating living beings to study questions identified with heartiness because of the vast scale cell and tissue changes (both hereditary and mechanical) that commonly happen over a generally brief period amid embryogenesis and the astoundingly abnormal state of reproducibility.
They utilized procedures from science, material science and designing to better see how the procedure of a solitary cell egg forms into a reasonable grown-up with such stunning exactness. The interdisciplinary research, with both exploratory and hypothetical individuals. His team goal is to gather quantitative information that can then be contrasted and sensible hypothetical models. These models are then used to make expectations which we test in the lab. For instance, utilizing lightsheet microscopy to picture entire Drosophila fetuses at subcellular determination. This empowers us to investigate, for instance, how singular cell destinies are identified with life form level scaling.
Interface of Biology and Theoretical Computer Science (BTCS) episode offered by developmental biologist, biophysicists, molecular biologist, and computational & evolutionary biologist focused on aspects of biology and theoretical computer science draw connections between biology and mathematics.