The body by metabolism?

Q1.Which of the following vitamin is endogenously formed in the body by metabolism?
a) Niacin
b) Cobalamin
c) Folic acid
d) Pantothenic acid
Expln
 Endogenously formed vitamins by intestinal flora is Vit K, Biotin, Pantothenic acid
 Endogenously formed vitamins by body metabolism is Vitamin D and Niacin

Q2.Which of the following interferes with absorption of Calcium?
a) Phytates of cereals
b) Vitamin D
c) Proteins in diet
d) Alkaline pH
Two answers are possible here

Q3.During exercise ,most rapid way to synthesize ATP is
a) Glycogenolysis
b) Glycolysis
c) Phosphocreatine
d) TCA Cycle
Expln
Harper 30/e page 662 ,its given Creatine Phosphate prevent rapid depletion of ATP by
providing a readily available high energy phosphate that can be used to regenerate ATP
from ADP in muscle.

Q4.Ammonia from brain is detoxified as
a) Glutamate
b) Glutamine
c) Alanine
d) Urea
Expln
 Ammonia from the brain and most other tissue is detoxified as Glutamine.The
enzyme is Glutamine Synthestase.This is called as first line trapping of Ammonia.
 Ammonia is transported as Alanine from muscle.
 Urea cycle does not operate in the brain

Q5.CpG island in human genome is related to
a) tRNA synthesis
b) DNA methylation
c) DNA Acetylation
d) Replication initiation
Expln
 Cytosine of the CpG islands are the most common site of DNA
methylations.Promoters of Transcription are rich in CpG islands.

Q6.Which of the following have a positive charge in physiological pH?
a) Arginine
b) Aspartic acid
c) Isoleucine
d) Valine
At physiologicalpH positive charge is for Histidine,Arginine and Lysine.

Q7.One of the common intermediate in steroid hormone synthesis from Cholesterol?
a) 7 dehydrocholesterol
b) Pregnenalone
c) ?
d) ?

Q8.All occurs in mitochondria EXCEPT
a) Fatty acid synthesis
b) Beta oxidation of fatty acid
c) DNA Synthesis
d) Protein synthesis
Expln
Mitochondrial DNA there is DNA synthesis,and Protein Synthesis
Fatty acid synthesis otherwise given in Harper as Extramitochondrial fatty acid Synthase
system.