The Antinucleolar antibody

A 45-year-old woman has pain in her fingers on exposure to cold, arthralgias, and difficulty swallowing solid food. The most useful test to make a definitive diagnosis would be

a. Rheumatoid factor

b. Antinucleolar antibody

c. ECG

d. BUN and creatinine

Answer:

b. Antinucleolar antibody