Rate lmiting step for gluconeogenesis?

1.10 years old boy presented with muscle weakness and fatigue with increased lead in blood. Which of following enzyme production in the liver is increased?

Ferrochetalase

PBG deaminase

Heme oxygenase

ALA synthase

2.The transmembrane region of a protein is likely to have -

(AI04)

A stretch of hydrophilic amino acids

A stretch of hydrophobic amino acids

A disulphide loop

Alternating hydrophilic and hydrophobic amino acids

3.Rate lmiting step for gluconeogenesis ?
A. Fructose 1,6 bisphosphate
B. Phospho enoylpyruvate carboxy kinase