Meconium ileus is associated with -
1.Fibrocystic disease of pancreas
3.Cirrhosis of liver
Meconium ileus is a neonatal manifestation of cystic fibrosis (also k/a fibrocystic ds. of pancreas)
In cystic fibrosis there is pancreatic enzyme deficiency and abnormal chloride secretion in the intestine that results in the production of viscous water-poor meconium.
Meconium ileus results because of impaction of this thick meconium in the ileum.
Meconium ileus presents shortly after birth with progressive abdominal distention and failure to pass meconium with intermittent bilious vomiting.
Abdominal x-ray shows
dilated loops of small intestine.
air-fluid levels do not form inspite of complete small intestinal obstruction, because the enteric contents are viscous and thick.
small bubbles of gas become entrapped in the inspissated meconium in the distal ileum, where they produce a characteristic ‘ground glass’ appearance on radiograph.
In complicated meconium ileus in which perforation has occurred, intraperitoneal egg-shell calcifications are noted.