Mammalian genome contains maximum gene that code for receptors of

MCQs AIIMS
#1

  1. Mammalian genome contains maximum gene that code for receptors of
    a. Odorants
    b. Interleukins
    c. Immunoglobins
    d. Growth factors

  2. All of the following can be used to precipitate protein except(Repeat question)
    a. Heavy metals
    b. Alcohol and acetone
    c. Precipitate at pH other than isoelectric pH
    d. Trichloracetic acid
    ***Preciptation occurs when pH move towards isoelectric pH

  3. A female infant appeared normal at birth but developed signs of liver disease one month of age and muscle weakness
    at 3 months and severe hypoglcemia on early morning awakening. Examination revealed hepatomegaly, laboratory
    analysis showed ketoacidosis, pH 7.2, increased AST and ALT over 1000IU… Intravenous administration glucagon
    followed by meals normalised blood levels, but glucose levels did not rise when glucagon was administered overnight
    fast. Liver biopsy was done and glycogen constituted (8%) of wet weight. With the above picture which of the
    following enzyme is deficient
    a. Debranching enzyme
    b. Glucose 6 phosphatase
    c. Muscle phosphorylase
    d. Branching enzyme
    Identifying features of Cori’s Disease
     Early morning hypoglycemia means fasting hypoglycemia-characteristic of Liver GSDs
     Liver GSD with muscle weakness
     Hepatomegaly
     Elevated ALT and AST
     IV Glucagon following overnight fast do not respond
     Liver Glycogen Content is 5% normally its increased to 8% as debranching enzyme defective

  4. Lipase that Is regulated by glucagon
    a. Lipoprotein lipase
    b. Hormone sensitive lipase
    c. Gastric lipase
    d. Pancreatic lipase
    Hormone Sensitive lipase is activated by:
     Glucagon
     Catecholamines (Epinephrine & Norepinephrine)
     ACTH
     TSH
     Glucocorticoids
     Thyroid Hormones.
     Growth hormone.
     α and β Melanocyte Stimulating Hormone (MSH)
     Vasopressin
    Hormone sensitive Lipase is inactivated by
     Insulin
     Nicotinic Acid
     Prostaglandin E1

5.Which of the following is not a glucogenic substrate in humans
a. Lactate
b. Oxaloacetate
c. Pyruvate
d. Acetyl CoA

6)A child ingested cyanide and rushed to the emergency room. Which of the following enzymes of citric acid cycle
is inhibited at the earliest
a. Citrate synthase
b. Aconistase
c. Acetyl CoA production
d. NAD donor
Two closely related answers are here,NAD+ donor and Acetyl CoA production
As there is a word ,earliest NAD+ donor is a better answer.Because as Cyanide inhibit Cyt c Oxidase,it inhibit the
the electron transfer of ETC,hence cannot accept electrons from reducing equivalents like NADH,so NAD+ donor
is affected.This inturn affect Acetyl CoA production,as NAD+ is a component of PDH,hence acetyl CoA production
is affected.So Pyruvate to Lactate…hence metabolic acidosis.