Immunohistochemical marker for sentinel node biopsy for breast carcinoma is?
1.Cytokeratin
2.Vimentin
3.Calretinin
4.CD45
exp:
Intermediate filaments of cytoskeleton are the major antigens used in immunohistochemistry. There are five major types of intermediate filaments.
- Cytokeratin – Carcinoma
- Vimentin - Sarcoma
- Desmin - Leiomyoma/Leiomyosarcoma , Rhabdomyoma/Rhabdomyosarcoma.
- Glial fibrillary acid protein (GFAP) - Astrocytoma, Ependymoma
- Neurofilament - Pheochromocytoma, Neuroblastoma