Hormones is consistent with the effects of anorexia nervosa?

NEET PG Medicine
#1

An elevation in which of the following hormones is consistent with the effects of anorexia nervosa?

  1. Cortisol
  2. GnRH
  3. Leptin
  4. Thyroxine (T4)

View Explanation

Regulation of virtually every endocrine system is disturbed in patients wth anorexia nervosa (AN).

Hypothalamic amenorrhea reflects diminished production of GnRH.

Serum leptin levels are reduced due to decreased mass of adipose tissue, and this is thought to be the mediator of the other neuroendocrine abnormalities associated with AN.

Thyroid function tests resemble the pattern seen in euthyroid sick syndrome (low-normal or depressed TSH and T4, depressed T3, increased reverse T3).

Serum cortisol and 24-h urine free cortisol are generally elevated without the expected clinical consequences of hypercortisolism.