All cells have pleomorphic, swollen mitochondria that are reduced in number (
diagnostic finding)
● Liver — fatty liver with minimal inflammation (Microvesicular Steatosis ) and
glycogen depletion.
● Hepatic mitochondrial dysfunction results in hyperammonemia, which is thought
to induce astrocyte edema, resulting in cerebral edema and increased intracranial
pressure (ICP).
In normal liver—
a) Collagen Type 1 and 3 is present at— portal tract and around Central vein .
b) Collagen Type 4 present in Space of Disse
■ In Cirrhotic liver----
Collagen Type 1 and 3 both are present at space of disse.