Harrison’s 19th E update on PD
Treatment
- Drug of choice for PD - Levodopa
- Drug of choice in young onset PD - Pramipexole
- Drug of choice to reduce motor fluctuation of levodopa - Pramipexole
- Drug of choice for ON-OFF phenomena - Rasageline
- Carbidopa : Levodopa ratio = 1:4 or 1:10
- COMT inhibitor like Entecapone combined with Levodopa - To increase Levodopa bioavailability and duration of action.
- Only disease modifying drug class or neuroprotective - MAO inhibitor.
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