Genetic disorders,neoplasia

  1. Deficiency in homogentisic oxidase results in this condition which manifests with black discoloration of the urine.
    A. albinism B. phenylketonuria
    C. ochronosis D. galactosemia

  2. This is the most common genetic cause of mental retardation.
    A. trisomy 18 B. trisomy 21
    C. chromosome 5p
    D.Turner syndrome

  3. A 10 year old female consulted due to multiple neurofibromas, cutaneous café aulait macules and pigmented iris hamartomas. This condition is called

A. tuberous sclerosis B. Von Recklinghausen’s disease
C. Marfan’s syndrome D. Von HippelLindau syndrome

  1. Chemical carcinogen implicated in the causation of mesothelioma.
    A. arsenic B. vinyl chloride
    C. asbestos D. nickel

  2. Human papilloma virus type responsible for cervical carcinoma.
    A. 2 and 4 B. 16 and 18
    C. 20 and 40 D. 6 and 11

  3. Most common paraneoplastic syndrome associated with squamous cell
    carcinoma of the lung.
    A. hypercalcemia B. Cushing syndrome
    C. SIADH D. carcinoid syndrome

  4. Extremely radiosensitive
    testicular tumor that tends to spread to lymph nodes
    along the iliac arteries and aorta.
    A. teratoma B. seminoma
    C. embryonal carcinoma D. adenocarcinoma

  5. Which of the following is characteristic of a malignant tumor.
    A. welldifferentiated
    B. slow growing
    C. cohesive and welldemarcated
    D. metastasis

  6. Tumor marker for breast cancer.
    A. CA125
    B. CA199
    C. CA153
    D. CA201