Q-9. Loop diuretics such as furosemide act by: (NEET Based)
a) Decreasing tubular reabsorption of Na+ and increase GFR
b) Decreasing H+ secretion with resultant increase in Na+ and K+ excretion
c) Inhibiting Na±K±2Cl- co-transporter in the medullary thick ascending limb
d) Inhibiting Na±K+ exchange in the collecting duct
Answer: Inhibiting Na±K±2Cl- co-transporter in the medullary thick ascending limb
High ceiling loop diuretics act by causing inhibition of Na+K+2Cl- co-transporter in thick ascending limb of loop of henle.
Loop diuretics abolish cortico-medullary osmotic gradient and decrease positive and negative free water clearance.