Which of the following substances produced by osteoclasts is responsible for digestion of minerals during bone resorption?
A. Hydrochloric acid
B. Acetic acid
C. Cathepsin K
D. Sclerostin
Correct answer : A. Hydrochloric acid
Osteoclasts on the surface of a boneOsteoclasts – cells responsible for bone resorption
Mature osteoclasts attach to bone and form a tight sealing zone.
They secrete hydrochloric acid and proteolytic enzymes like cathepsin K.
HCl is involved in digestion of bone minerals.
Cathepsin K is responsible for degradation of collagen.
Sclerostin (SOST) is a glycoprotein produced by osteocytes which inhibits bone formation.
Ref: Davidson’s Principles and Practice of Medicine, 22nd Edition, p1062