Chronic ITP is due to:

Chronic ITP is due to:

1.Increased platelet consumption intravascularly
2.Antibody production against platelets
3.Decreased synthesis
4.Decreased megakaryocytes

sol:

a. Idiopathic thrombocytopenic Purpura (ITP)

b. Also referred as autoimmune thrombocytopenia and is acute and chronic type.

c. Both forms of ITP are associated with increased platelet destruction and normal megakaryocytes in the bone marrow

d. Acute ITP occurs most often in adult, particularly in women of child bearing age

Pathogenesis:

a. The plasma of patients with ITP causes a rapid fall on platelet count when transfused in to normal recipients

b. Normal platelets are rapidly destroyed when administered to patient with ITP

c. Chronic ITP have autoantibodies directed against platelets

d. About 75 -80% of patients are remarkably improved by splenectomy which suggested that spleen is the major site of removal of sensitized platelets.

e. The spleen is normal size and bone marrow is also normal

f. An increased number of megakaryocytes is usually seen. But splenomegaly, lymphadenopathy and decrease in the number of megakaryocytes virtually rules out the
diagnosis of ITP

g. Treatment by platelet transfusion in children and adult both