Chronic immunosuppressive therapy develops bacterial sinusitis

A 52-year-old heart transplant patient receiving chronic immunosuppressive therapy develops bacterial sinusitis. His list of medications includes cyclosporine. The patient’s physician decides to start him on antibiotic therapy but is having difficulty choosing between amoxicillin and erythromycin to treat the infection. Compared to using each agent alone, concurrent use of erythromycin and cyclosporine would most likely lead to which of the following?

(A) Decreased risk of renal failure
(B) Increased cyclophilin concentration
© Increased cyclosporine serum concentrations
(D) Increased risk of infection with Clostridium difficile
(E) Increased risk of QTc prolongation