AIIMS NOV 2015: Pharmacology (Solved Paper with explanation)

Q-1. A pregnant female with manic episode for 2 weeks; previously 3 episodes of mania in 5 years and 1 episode of depression. What should be given for treatment?
a) Lithium
b) Clonazepam
c) Haloperidol
d) Promethazine

Q-2. Store a drug in a cool place refers to
a) Below freezing point of water
b) 0 degree C
c) 2-8 degree C
d) 8 to 15 degree C

Q-3. Which drug can cause progressive visual field constriction?
a) Phenobarbitone
b) Vigabatrine
c) Ethosuximide
d) None

Q-4. Phase 1 clinical trial is for?
a) Pharmacokinetics
b) Dose
c) Safety
d) Efficacy

Q-5. Schedule of drug to be sold only on prescription?
a) Category H
b) Category X
c) Category S
d) Category P

Q-6. Antidote for overdose of fibrinolytic therapy
a) Heparin
b) Epsilon-amino-caproic acid
c) Protamine
d) None

Q-7. Which cannot be used as emergency contraceptive?
a) IUCD
b) Ulipristal
c) Levo-norgestrel
d) Desogestrel
Answer: Desogestrel
Explanation:
Drugs used in emergency contraceptive:
Estrogen alone (Within 72 hours):
Ethinyl estradiol for 5 days
Conjugated estrogen for 5 days
Progesterone alone (Within 72 hours):
Levo-norgestrel
Estrogen and Progesterone (Within 72 hours):
Ethinyl estradiol and Levo-norgestrel
Low dose OCP
Cu-T 380 A- Inserted within 7 days from the time of unprotected intercourse.
Mifepristone
Danazole
Important point:
A single dose of 30 mg Ulipristal acetate, a novel selective progesterone receptor modulator, has recently been proposed for the emergency contraception use up to 120 h of unprotected intercourse with similar side effect profiles as levo-norgestrel.

Q-8. All are used in influenza B except
a) Oseltamivir
b) Zanamivir
c) Peramivir
d) Ribavarin

Q-9. What is not used in detoxification of chronic alcohol dependence?
a) Acamprosate
b) Flumazenil
c) Naltrexone
d) Disulfiram

Q-10. Dopamine in dose concentration at 3-5mcg/kg/min acts predominantly on?
a) Beta-1
b) D-1
c) Alpha-1
d) None
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