A dense infiltrate of lymphocytes

A 58-year-old woman has a screening mammography and is found to have a 4-cm circumscribed mass, without calcifications, in her left breast. An excisional biopsy shows solid nests and sheets of highly pleomorphic cells, with many mitotic figures, surrounded by a dense infiltrate of lymphocytes. Which of the following is the most likely diagnosis?

image

  1. Invasive ductal carcinoma
  2. Invasive lobular carcinoma
  3. Medullary carcinoma
  4. Paget disease
  5. Phyllodes tumor