A 24-year-old woman is newly diagnosed with systemic lupus erythematosus. Which of the following organ system complications is she most likely to have over the course of her lifetime?
1.Cardiopulmonary
2.Cutaneous
3.Hematologic
4.Musculoskeletal
5.Renal
sol:
Systemic lupus erythematosus is a multisystem disease with diverse organ involvement and multiple different manifestations within an organ system. The system most commonly involved is the musculoskeletal system, with 95% of patients having involvement, usually as arthralgias or myalgias. Arthritis is also common and is one of the diagnostic criteria for SLE. Cutaneous and hematologic disease occurs in approximately 80–85% of patients. Neurologic and cardiopulmonary diseases affect approximately 60% of patients, while renal and gastrointestinal diseases occur in less than 50% of cases.